Waxaa la ogaaday in α-solanine, oo ah sun sun ah oo laga helo dhirta baradhada, in laga soo qaatay dhadhanka qadhaadh ee α-tomatine, kaas oo laga helo dhirta yaanyada, war-saxaafadeed ka soo baxay jaamacadda Kobe ayaa lagu sheegay March 26. Baarayaasha Jaamacadda Kyoto , Xarunta RIKEN ee Sayniska Kheyraadka Joogtada ah iyo Jaamacadda Osaka, ayaa sidoo kale qeyb ka ahaa shaqada cilmi baarista.
Baarayaasha waxay baareen dariiqa loo yaqaan'α-solanine biosynthesis 'ee dhirta baradhada. Iyagoo adeegsanaya sixitaanka genome-ka, waxay carqaladeeyeen hiddo-wadaha noolaha ee loo yaqaan 'biosynthetic enzyme' ee ku jira baradho si uusan awood ugu yeelan inuu soo saaroα-solanine. Quudinta α-tomatine ee carqaladeeya ka dib waxay dhalisay u beddelid dheef-shiid kiimikaad oo u dhigma xarunta solanidane ee u dhiganta, qoraallada sii deynta.
Hidde-2-oxoglutarate ku tiirsan dioxygenase (DPS) hiddo oo lagu muujiyey baradho inta lagu guda jiro isku-dhafka so-solanine ayaa markaa si gaar ah loo soocay. Baadhitaan dheeri ah, cilmi baarayaashu waxay soo saareen dhir la beddelay taas oo muujinta hidda-wadaha DPS lagu xakumay faragelinta RNA.
"Soo uruurinta solanidane ee dhirta baradhada ah ee wax laga badalay ayaa aad uga hooseysay kooxdan aan wax laga badalin, iyo spirosolanes oo ku urursan gudaha dhirta halkii laga heli lahaa solanidanes," ayaa lagu yiri sii deynta.
Waxqabadka enzymatic ee DPS iyada oo la isku daro borotiinada laguna muujiyo E. coli ayaa markaa la cabiray. Natiijooyinku waxay muujiyeen doorka kalluumeysiga gaarka ah ee DPS ee spirosolane oo loo beddelay solanidane - taasoo caddaynaysa in DPS ay tahay enzyme muhiim ah oo mas'uul ka ah beddelaaddan.
Cilmi baarista ayaa muujisay sida baradhada ay u awoodaan inay soo saaraan α-solanine, iyadoo ay ugu wacan tahay isbeddelka DPS, oo mas'uul ka ah metroolista beddelka spirosolane.
Waa yaanyo la yaqaan sidoo kale waxay leeyihiin enzyme lagu shiido spirosolanes. Dhadhaminta qadhaadh ee α-tomatine waxaa laga helaa yaanyo aan bislaan laakiin waxaa lagu dhex galiyay dhadhan la'aan, esculeoside aan sun ahayn sida miraha u bislaadaan, qoraallada sii deynta.
Baradhadu waxaa lagu calaamadeeyay inay tahay cunno khatar ah maxaa yeelay isku-darka badan ee sunta α-solanine wuxuu sababi karaa sumowga cuntada. .
Rajada ayaa ah in natiijooyinka cilmi baaristaan loo adeegsan karo taranka baradhada iyadoo aasaas looga dhigayo cabudhinta soo saarista xeryahooda sunta ah, qoraallada sii deynta.